JDRF, the leading global type 1 diabetes (T1D) research and advocacy organization, has awarded $12 million to researchers Dr. Alessandro Doria with Joslin Diabetes Center, Dr. Michael Mauer with the University of Minnesota Medical School, and Dr. David Cherney at the University Health Network, University of Toronto, to conduct a pivotal clinical trial that will test sotagliflozin, a dual sodium-glucose cotransporter (SGLT)1 and SGLT2 inhibitor, in the treatment of kidney complications in people with T1D. The study will build on the SUGARNSALT research project first led by Dr. Cherney, which is supported by a $1 million commitment from The Kidney Foundation of Canada (KFOC) matched by a $1 million investment by the Canadian Institutes of Health Research (CIHR) through the Team Grant: Diabetes Mechanisms and Translational Solutions competition, launched in 2022.
Kidney disease remains a life-threatening complication for those living with diabetes. Almost half of kidney failure cases are caused by diabetes, and an estimated one out of three people with T1D develop significant kidney disease. In recent years, SGLT inhibitors have proven to be very effective in improving kidney outcomes in people with type 2 diabetes, but there remains a lack of research on their effectiveness for those with T1D and established diabetic kidney disease. With few approved therapies for people with T1D who have developed kidney disease and the substantial risk of kidney disease progression despite current treatments available for such patients, this study is an important step toward fulfilling an unmet clinical need and allowing these individuals to live longer and healthier lives.
The trial will be conducted at sites across the U.S. and Canada, and enrollment is expected to begin in May 2024.
To learn more about this award please visit (only in English): JDRF Awards $12 Million for Phase 3 Type 1 Diabetes Kidney Disease Clinical Trial, Joins The Kidney Foundation of Canada in Driving Research to Treat Kidney Disease – JDRF